Low HDL-C predicts subclinical atherosclerosis in asymptomatic South East Asian patients without known cardiovascular disease
We assessed the association between low HDL-C and subclinical atherosclerosis in asymptomatic individuals without known cardiovascular (CV) disease. 276 patients underwent B-Mode carotid ultrasound. Mean carotid artery intima-media thickness (CIMT) was measured. Subclinical atherosclerosis was defined as a mean CIMT >1.0mm. In a logistic regression analysis, HDL-C (OR = 0.94; 95% CI = 0.90 to 0.98; p < 0.01) was an independent predictor of subclinical atherosclerosis, as were age (OR = 1.06; 95% CI = 1.01 to 1.11; p = 0.01) and SBP (OR = 1.03; 95% CI = 1.00 to 1.06; p = 0.02). For every 1mg/dl decrease in HDL-C, the risk of developing subclinical atherosclerosis increased by 6%. In an asymptomatic South East Asian population, a low HDL-C was the only lipid parameter associated with development of subclinical atherosclerosis.
©2009 by MEDIMOND s.r.l.
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